Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage
نویسندگان
چکیده
منابع مشابه
Molecular determinants of melanocortin 4 receptor ligand binding and MC4/MC3 receptor selectivity.
The molecular basis of ligand recognition by the melanocortin 4 receptor (MC4R) has not been fully defined. In this study, we investigated the molecular determinants of MC4R ligand binding, employing a large array of ligands, using three approaches. First, molecular modeling of the receptor was used to identify Phe284, in transmembrane (TM) 7, as a potential site of ligand interaction. Mutation...
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Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown. Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial cells, and tubular epithelial cells. Podocyte...
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Evidence from animal studies suggests corticotrophin and melanocortin systems have regulatory role in feeding system in avian, but there is no evidence for their interaction. In this survey three experiments designed to investigate the role of corticotrophin receptors on food intake using melanocortin receptors agonist M3 and M4 in neonatal chicken (each experiment includes 4 groups and 11 bird...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2007
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0707115